The New Glutathione Supplement GlyNac

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A brief article on the benefits of a new compound supplement called Glynac, sent to me by a friend. It is glutathione and glycine. I did find one supplement that has the written about supplement but I didn’t purchase it due to the reasons stated in the video. I forget who produces all the Vitamin C (ascorbate) in the world but it’s the worst form. Sodium ascorbate is the best form. When I do find a Glynac supplement that I think is worth purchasing I will post it here. In the meantime I am posting just a pic reduced form of glutathione that I did find to be helpful. There is no need to purchase NAC with this product.

On to Glynac.

Glutathione Extends Lifespan in Mice by 24%

This compound seems to be valuable in controlling oxidative stress.

Glutathione (GSH) is the most abundant intracellular antioxidant, the backbone of natural defenses against ROS. It is a tripeptide composed of glycine, cysteine, and glutamic acid. GSH levels decline with age, so supplementing it could plausibly affect other processes of aging.

This can be achieved with GlyNAC, a combination of two GSH precursors, glycine and N-acetylcystein. GlyNAC has already been an object of several studies. The same group that is behind this new paper has previously shown that continuous GlyNAC supplementation alleviates mitochondrial dysfunction and improves mitophagy (degradation of dysfunctional mitochondria), nutrient sensing, and genome stability in humans.

Reduced Glutathione. A higher glutathione content than the supplement I mentioned in the video and the first glutathione supplement I tried that I was able to utilize.

From Immune For Life

Glutathione benefits:

- Probiotic intervention is useful for treatments and conditions that are known to rapidly decrease mucosal glutathione levels like radiation therapy and H. pylori infection. Lactobacillus Fermentum ME – 3 strain has a long history of being studied for well over 20 years. This particular lactobacillus probiotic strain is very unique and valuable. It is known to produce glutathione naturally in the body. Glutathione is renowned for its antioxidant function. Lactic acid bacteria maintains normal insulin levels in the blood and protects the liver.

Oral administration of substantive amounts of bovine whey protein enhances the glutathione content in the liver, heart and spleen. This change is moderate but sustained over time and biologically signiﬁcant. This property is restricted to the un-denatured conformation of whey protein.
Nutritional yeast contains vital food factors such as SOD, RNA/DNA, glutathione, trace minerals, Beta-glucans, GABA, amino acids, lipoic acid, polysaccharides, B-complex vitamins, minerals including GTF chromium and over 40 proteolytic enzymes.
After 12 weeks’ intervention, compared with the placebo, omega-3 fatty acids and vitamin E co-supplementation led to a significant improvement. Furthermore, co-supplementation decreased high-sensitivity C-reactive protein and increased total antioxidant capacity and glutathione (GSH) concentrations compared with the placebo.
Whey protein is rich in sulfhydryl amino acid cysteine, a precursor of glutathione.
As precursor of the antioxidant glutathione, whey protein is superior in nullifying the adverse effects of oxidative stressors. Whey protein increased lymphocyte glutathione (GSH) in humans.
Alpha-lactalbumin is a bioactive milk protein found in acid whey, typically containing 20-25% α-LA. This is nearly equal to that found in human breast milk.When α-LA is broken down (hydrolyzed) by the body it releases cysteine. Cysteine is a precursor to glutathione (GSH), a vital internal antioxidant. Alpha-lactalbumin has a direct effect on the body. It increases production of serotonin and glutathione. Alpha-lactalbumin increases liver glutathione after strenuous exercise.
The administration of glutathione itself is of little consequence on tissue glutathione levels, because it cannot be transported intact across the cell membrane. Some methods of increasing intracellular levels of glutathione concentration are either toxic or dangerous owing to the risks related to the initial phase of glutathione depletion. Undenatured whey protein of bovine origin increases glutathione in various tissues.
The uniqueness of whey proteins is due to their ability to boost the level of glutathione (GSH) in various tissues and to optimize the immune system.
Whey proteins exert a therapeutic effect on the gastric mucosa. This effect is due to the presence of sulfhydryl group in amino acid cysteine and its linkage with glutamic acid in the production of glutathione.
It has been widely observed that individuals suffering from cancer, chronic fatigue syndrome and many other immune-compromising conditions have very poor levels of glutathione. The sulphur-containing amino-acids (cysteine and methionine) are also found in high levels in whey protein.
Glutathione is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent.

Alternavita: All you need to know (critical info in a nutshell)..... by focusing exclusively on these foundational health and immune development issues up to 90% of chronic conditions can be eliminated.

WHO STATEMENTS: 2017 Millennium Goal

Breastfeeding,
food (security)
and water security (sanitation)

are major protective factors against malnutrition and critical factors in the maturation of healthy gut microbiota, characterized by a transient bifidobacterial bloom before a global rise in anaerobes. Early depletion in gut Bifidobacterium longum, a typical maternal probiotic, known to inhibit pathogens, represents the first step in gut microbiota alteration associated with severe acute malnutrition (SAM). Later, the absence of the Healthy Mature Anaerobic Gut Microbiota (HMAGM) leads to deficient energy harvest, vitamin biosynthesis and immune protection, and is associated with diarrhea, malabsorption and systemic invasion by microbial pathogens. A therapeutic diet and infection treatment may be unable to restore bifidobacteria and HMAGM.

Researchers found that malnourished children’s microbiota failed to follow the healthy pattern they identified in healthy children. The microbiota of malnourished children is immature, lagging in development behind that of their healthy peers. Supplementing these children’s meals with widely used therapeutic foods that increase calories and nutrient density reduces deaths from malnutrition, but it does not fix their persistent microbiota immaturity.

“Perhaps more insidious than slowing growth is malnutrition’s effect on less visible aspects of health, including impaired brain development and dysfunctional immunity, which follow these children throughout their lives”.

The Father of The Microbiome

Dr. Jeffrey Gordon

SIBO

SIBO can cause severe malabsorption, serious malnutrition and immune deficiency syndromes in children (non breastfed) and adults.

Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO.

Immunizations

The WHO recommends that immunization or treatment be orally administered due to economic, logistical and security reasons. Furthermore, this route offers important advantages over systemic administration, such as reducing side effects, as the molecules are administered locally and have the ability to stimulate the GALT immune responses (Levine and Dougan, 1998; Neutra and Kozlowski, 2006; Bermúdez-Humarán et al., 2011).

Infections

For ANY infectious or parasitic disease to start, it is ALWAYS a requisite that the host suffer IMMUNODEFICIENCY. At the same time, infectious and parasitic diseases themselves cause additional IMMUNE SUPPRESSION and more MALNUTRITION. This immune suppression is SECONDARY to the accumulation of free radicals, especially oxidizing species, that occurs during and after infectious and parasitic diseases.

Clinical Aspects of Immunology and Biochem J.

Current IBD Research 2016

Currently available treatments for IBD, which target the systemic immune system, induce immunosuppression, thereby exposing the patient to the risk of infections and malignancy. The interplay between the gut and the systemic immune system determines the final effect on target organs, including the bowel mucosa. Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs.

Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

Most importantly, the immune modulatory agents used today for IBD do not achieve remission in many patients.

Not all IBD patients benefit from currently available drugs. Young people with IBD do not want to be on long-term drug therapy. Oral immune therapy, while not yet studied in large cohorts of patients, may provide an answer to this unmet need.

Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

Tolerance

Tolerance is the ability of the immune system to ‘see’ and respond appropriately. Without galactose (a necessary sugar) the immune system can not 'see'. Your immune system would not be able to function without galactose Your body wouldn’t know which cells are “good” and what cells are “bad.” Your body wouldn’t know who the invaders were and which ones should be attacked by antibodies. As you will learn the importance of these ‘sugars’ in gut microbiota health is a rapidly expanding field of research, only recently discovered, including HMO's (human milk oligosaccharides).

Why galactose? Milk sugar aka lactose has been shown to be very beneficial for the human body though unlike sucrose, lactose is made up of glucose and galactose. There is no fructose in lactose. It is a healthy disaccharide sugar. Galactose is known as the “brain sugar” and supports brain development of babies and children. Galactose helps triggers long-term memory formation. Galactose has been shown to inhibit tumor growth and stop its spread, particularly to the liver. This beneficial sugar can also enhance wound healing, decrease inflammation, enhances cellular communication, and increases calcium absorption.
What does immune ‘tolerance’ mean in simple language?
Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in a given organism. The Th1 cytokine profile is vital for clearance of certain organisms and ancillary immune activity, and a limiting effect on this cytokine profile may result in reduced chances for overcoming infections especially intra-cellular organisms residing within macrophages. Effective clearance will depend on appropriate macrophage activation (which occurs through IFN≥ release by Th1 and NK cells) and production of nitric oxide. If this pathway is disrupted IFN≥ secretion is blocked, impairing macrophage activation. Persistent blockade of these inhibitory receptors has lead to the breakdown in immune self tolerance, thereby increasing susceptibility to autoimmune or auto-inflammatory side effects, including rash, colitis, hepatitis and endocrinopathies. Many drugs may cause checkpoint blockade toxicity including pharmaceutical drugs termed ‘immuno therapy’ by pharmaceutical companies, these include Mab drugs and cancer treatments. Checkpoint Inhibitor–Induced Colitis: A New Type of Inflammatory Bowel Disease? Madeline Bertha, MD MS, corresponding author1 Emanuelle Bellaguara, MD, Timothy Kuzel, MD, and Stephen Hanauer, MD ACG Case Rep J. 2017; 4: e112. Published online 2017 Oct 11. doi: 10.14309/crj.2017.112 PMCID: PMC5636906 PMID: 29043290

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