I know I haven’t been keeping up with gut health developments since around 2018 aside from clinical applications and directives regarding breast feeding and infant formula but here is another video with a statement that took me by complete surprise.
Most aren’t familiar with the bodies strewn on this hill regarding the strong associations between gut health and ‘modern’ diseases like autism and other autoimmune disorders but I am so this is another admission that was a long time coming. And they actually used the word ‘cause‘. Not their usual jargon; you can’t get to B without A as in ‘if present’ but won’t ’cause’ disease ‘unless and until’ is a condition or term not a ’cause’….. Cause means cause, noun, reason for an action or condition. Astounding. I doubt the apologies are forthcoming to Andrew Wakefield among others whose career was destroyed for asking the question. I just kind of despise these groups frankly Stanford etc., who swoop in to collect the money once they’ve been presented with overwhelming evidence produced by others that they can no longer deny with a straight face. They seem incapable of a good end, an impossibility for a relativist. You have to empower people to achieve the best health outcome via their own circumstance, not rely on you forever for a drug, that’s a drug dealer trying to justify his own trade. We must be precise because they are not.
The real purpose for this research is for further vaccine development, nothing else.
I have no problem with the research in to ancient microbiota composition of hunter/gatherers or agrarian cultures. I have no problem understanding the importance or factors influencing acclimation. This might lead to better products with ideal probiotic compositions as these ancient cultural diets generally did not ignore breastfeeding, acclimation or weaning out of necessity and got the ideal diet (any extra food source was considered a plus) and eventually for a short window enjoyed the benefits of abundant high quality food and proper sanitation in addition. Who wouldn’t want that, it’s addressing all 3 conditions.
I do have a problem with attempting to influence hierarchy of risk factors:
Breastfeeding
food (security, quality, safety)
and water security (sanitation)
The diets she mentions will not favorably reverse the chronic conditions in the absence of breastfeeding to reverse ‘the fundamental cause’ or hierarchy of risk #1 factor. It’s like building a house, the house begins with the foundation, it doesn’t matter what comes after if the foundation is poor. I didn’t just pull the frontiers of gut/ immune research out of my butt and neither did they (natural oral immune therapy to restore gut/immune and generational health not rescued by diet aside from the mammalian milk diet).
Not to mention, do the search yourself. Just by the initial topic (microbiome) and dates somebody suspected some major correlation, oh along about 1950.
Why do I have this fear of toddler adult diet to the rescue?
Because there are some who are so heavily invested in being a ‘diet guru’ that they are out there as we speak claiming that milk is harmful or not studied (neither is true at all) and no matter how you slice it the essential components of oral immune therapy and/or reversing SAM (and the other 7000 conditions) are derived from a mammal milk product whether it be colostrum or any other effective immune therapeutic available as a ‘medicine’ and the process is not entirely replicated in other food forms, mammal milk is essential to the molecular process whether it becomes an amide, a peptide or disaccharide via fermentation. Of all the food demonization going on out there, this one is particularly malicious and some big money is behind it. It follows they want to get rid of cows too under a false pretense. This is the only readily available food known to prevent kwashiorkor; aside from acid whey, a suitable replacement for whole fat mammal milk, in every country including school lunch programs.
If you try to reframe that a mammal doesn’t require a mammalian milk diet at birth and benefits extend far beyond that timeframe; that species is doomed. Period.
If any other diet sufficed, formula would still be sufficient, it’s not and it has been declared as not sufficient for brain or immune development.
At least one famous diet guru has changed course regarding ’cause’. The vegans will be the last to fall (hunter/gatherer was your second diet, not the first and definitely not throughout majority of mammalian species biological history since the beginning of procreation).
So that being said, the video is a helpful educational tool and you can always enhance diet (that’s quality). You can also learn what diets destroy proper development.
Even a calf who had the best start, colostrum/weaning/acclimation as I mentioned with the best quality pasture/water will benefit from kefir as a mammal as it boosts the inherent gains against many environmental assaults. But speaking of which; now that she illustrates that part of your acclimation and microbiota formation process is species related; the golden rule applies. Take care of your mammal friends. Not that you didn’t know that, a sick animal is not fit for consumption.
Fermented natural foods are part of the local acclimation process as organism compositions vary throughout the world.
Invest in the ones moving toward widespread clinical applications that we already know are beneficial and not harmful and robust, enforced clinical directives, the trailblazers (Japan); not the Come Late To The Party however helpful additional information might be due to extinction of human subjects and complete loss of traditional cultural diets. With knowledge you can extend the window of time before dietary lifestyle choices and malnutrition cause permanent issues. The closest simulation to breastfeeding is likely not lifetime protective but requires lifetime maintenance. Maybe if this ‘breastmilk simulation’ for the non breastfed is started before age 5-7 the effects will be longer lasting approaching near equality but:
we don’t know as this is truly the largest and most unique fundamental human experiment (cross culture) ever attempted in history.
This is just the problem I have with the system, often these studies are meant to delay or reroute application and funnel funding and as I said the end result of this from Stanford is going to be vaccine development so it’s already suspect. There are already colostrum based immune therapy medicines on the market, publicly traded just like any other medicine with years of research behind them. They pretend research or these products don’t exist and are already fulfilling unmet needs, worldwide.
If I sat around waiting for Stanford, I’d be dead and so would many others be dead from chronic diarrhea.
Gut Microbiota as a Lever to Improve Human Health
Ok, I didn’t read the paper but I found out who did it. ASU was the group attempting to create and patent synthetic gcmaf. They didn’t succeed. I believe it was simultaneous with Japan gcmaf first generation approx. 2005.
Research
For several years now, research has also shown that it is possible to transfer depression via microbiota transplant. For example, in 2016 a paper was published wherein scientists took the microbiota from depressed humans, and transferred it into rats, inducing, “…behavioral and physiological features characteristic of depression in the recipient animals…”[ii]
Then came Jim Adams and colleagues, at Arizona State University, who used fecal transplant in an open-label study in autism, and found that they could confer an 80% reduction in GI symptoms and also radical improvement in the symptoms of autism in the children: “…clinical assessments showed that behavioral ASD symptoms improved significantly and remained improved 8 weeks after treatment ended.”[iii] It was huge news, a couple of months ago, when the follow up study was published by these same scientists, which showed that the gains these children had made were retained 2 years later: “…most improvements in GI symptoms were maintained, and autism-related symptoms improved even more after the end of treatment.”[iv] (This of course makes perfect sense. GI symptoms were mostly maintained but of course, would be diet dependent. And autism symptoms like speech issues require months of therapy to show improvement. If the microbiota transplant worked, you’d expect the children to be able to learn better and more efficiently, and improve continually over time.)
Having read these, and many other such studies over the years, the latest big biome news in the autism world came as absolutely no surprise to me. Last week, researchers at the California Institute of Technology reported that the symptoms of autism can be transferred to mice via FMT.[v] They took germ-free mice, infused them with the gut bacteria from children on the autism spectrum, and low and behold: “…these mice were less vocal than the mice in the control group. They also tended to engage in more repetitive behaviors and spent less time interacting with other mice.”[vi] They also found differences in the brains of the treated mice, including changes in certain molecules (metabolites) which were at lower levels in the “ASD” mice. These particular metabolites, taurine and 5AV (5-amonovaleric acid) affect the levels of GABA in the brain, a neurotransmitter responsible for calming neurons down after they’ve been stimulated. Many kinds of seizures, which involve abnormal neuronal excitement, for example, are associated with low levels of GABA. And abnormal levels of GABA have long been associated with autism spectrum disorders.
The researchers took the research a step further and gave 5AV and taurine to a particular kind of mouse (called BTBR) which has been bred to have autism-like behaviors: “The study found that treating the mice with either 5AV or taurine led to noticeable decreases in the characteristic ASD-like behaviors…And, when the researchers examined brain activity in these mice, they found a strong link between increases in the levels of 5AV and decreased excitability in the brain.” To summarize: giving the mice gut bacteria from children with autism not only caused behavioral changes consistent with autism, but also caused chemical changes in the brain that parallel known alterations found in those on the spectrum.
Sorry I forgot to flip screen views for you.
The result is the same in every mammal.... they never thrive
Supplementing these children’s meals with widely used therapeutic foods that increase calories and nutrient density reduces deaths from malnutrition, but it does not fix their persistent microbiota immaturity.
“Perhaps more insidious than slowing growth is malnutrition’s effect on less visible aspects of health, including impaired brain development and dysfunctional immunity, which follow these children throughout their lives”.
The Father of The Microbiome
Dr. Jeffrey Gordon
Mass Vax Die Off Stuns Scientists! – While Americans Drop, Africans Thrive!
Alternavita: All you need to know (critical info in a nutshell)..... by focusing exclusively on these foundational health and immune development issues up to 90% of chronic conditions can be eliminated.
WHO STATEMENTS: 2017 Millennium Goal
- Breastfeeding,
- food (security)
- and water security (sanitation)
are major protective factors against malnutrition and critical factors in the maturation of healthy gut microbiota, characterized by a transient bifidobacterial bloom before a global rise in anaerobes. Early depletion in gut Bifidobacterium longum, a typical maternal probiotic, known to inhibit pathogens, represents the first step in gut microbiota alteration associated with severe acute malnutrition (SAM). Later, the absence of the Healthy Mature Anaerobic Gut Microbiota (HMAGM) leads to deficient energy harvest, vitamin biosynthesis and immune protection, and is associated with diarrhea, malabsorption and systemic invasion by microbial pathogens. A therapeutic diet and infection treatment may be unable to restore bifidobacteria and HMAGM.
Researchers found that malnourished children’s microbiota failed to follow the healthy pattern they identified in healthy children. The microbiota of malnourished children is immature, lagging in development behind that of their healthy peers. Supplementing these children’s meals with widely used therapeutic foods that increase calories and nutrient density reduces deaths from malnutrition, but it does not fix their persistent microbiota immaturity.
“Perhaps more insidious than slowing growth is malnutrition’s effect on less visible aspects of health, including impaired brain development and dysfunctional immunity, which follow these children throughout their lives”.
The Father of The Microbiome
Dr. Jeffrey Gordon
SIBO
SIBO can cause severe malabsorption, serious malnutrition and immune deficiency syndromes in children (non breastfed) and adults.
Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO.
Immunizations
The WHO recommends that immunization or treatment be orally administered due to economic, logistical and security reasons. Furthermore, this route offers important advantages over systemic administration, such as reducing side effects, as the molecules are administered locally and have the ability to stimulate the GALT immune responses (Levine and Dougan, 1998; Neutra and Kozlowski, 2006; Bermúdez-Humarán et al., 2011).
Infections
For ANY infectious or parasitic disease to start, it is ALWAYS a requisite that the host suffer IMMUNODEFICIENCY. At the same time, infectious and parasitic diseases themselves cause additional IMMUNE SUPPRESSION and more MALNUTRITION. This immune suppression is SECONDARY to the accumulation of free radicals, especially oxidizing species, that occurs during and after infectious and parasitic diseases.
Clinical Aspects of Immunology and Biochem J.
Current IBD Research 2016
Currently available treatments for IBD, which target the systemic immune system, induce immunosuppression, thereby exposing the patient to the risk of infections and malignancy. The interplay between the gut and the systemic immune system determines the final effect on target organs, including the bowel mucosa. Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs.
Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel
Most importantly, the immune modulatory agents used today for IBD do not achieve remission in many patients.
Not all IBD patients benefit from currently available drugs. Young people with IBD do not want to be on long-term drug therapy. Oral immune therapy, while not yet studied in large cohorts of patients, may provide an answer to this unmet need.
Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel
Tolerance
Tolerance is the ability of the immune system to ‘see’ and respond appropriately. Without galactose (a necessary sugar) the immune system can not 'see'. Your immune system would not be able to function without galactose Your body wouldn’t know which cells are
“good” and what cells are “bad.” Your body wouldn’t know who the invaders were and which ones should be attacked by antibodies. As you will learn the importance of these ‘sugars’ in gut microbiota health is a rapidly expanding field of research, only recently
discovered, including HMO's (human milk oligosaccharides).
Why galactose?
Milk sugar aka lactose has been shown to be very beneficial for the human body though unlike sucrose, lactose is made up of glucose and galactose. There is no fructose in lactose. It is a healthy disaccharide sugar. Galactose is known as the “brain sugar” and supports brain development of babies and children. Galactose helps triggers long-term memory formation. Galactose has been shown to inhibit tumor growth and stop its spread, particularly to the liver. This beneficial sugar can also enhance wound healing, decrease inflammation, enhances cellular communication, and increases calcium absorption.
What does immune ‘tolerance’ mean in simple language?
Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to
substances or tissue that have the capacity to elicit an immune response in a given organism. The Th1 cytokine profile is vital for clearance of certain organisms and ancillary immune activity, and a limiting effect on this cytokine profile may result in reduced chances for overcoming infections especially intra-cellular organisms residing within macrophages.
Effective clearance will depend on appropriate macrophage activation (which occurs through IFN≥ release by Th1 and NK cells) and production of nitric oxide. If this pathway is disrupted IFN≥ secretion is blocked, impairing macrophage activation.
Persistent blockade of these inhibitory receptors has lead to the breakdown in immune self tolerance, thereby increasing susceptibility to autoimmune or auto-inflammatory side effects, including rash, colitis, hepatitis and endocrinopathies.
Many drugs may cause checkpoint blockade toxicity including pharmaceutical drugs termed ‘immuno therapy’ by pharmaceutical companies, these include Mab drugs and cancer treatments.
Checkpoint Inhibitor–Induced Colitis: A New Type of Inflammatory Bowel Disease?
Madeline Bertha, MD MS, corresponding author1 Emanuelle Bellaguara, MD, Timothy Kuzel, MD, and Stephen Hanauer, MD
ACG Case Rep J. 2017; 4: e112.
Published online 2017 Oct 11. doi: 10.14309/crj.2017.112
PMCID: PMC5636906
PMID: 29043290
The Elderly
Mammal milk is required for enhanced phagocytosis as shown by research, especially in the elderly. Whole fat mammal milk can actually restore phagocytosis in senescent cells in the elderly. Phagocytosis, by which immune cells ‘eat’ bacteria or infected cells, is one of the mechanisms that help to resist infections. Lactic acid bacteria strains like acidophilus also increases phagocytosis.
If you want the good stuff…
As comparable to Garden of Life…. 50 or more organism kefir available on her site, takes a lot of daily/weekly work but the times may call for it….
11-23-21
* Not necessary for conversion gc protein in bovine colostrum to maf but if you want it go for it, the temp. is fine (room temp). Garden of Life has 28 strain European kefir grains. Most store bought has 12 strains or less (quality control). They no longer sell 50+ kefir strains (freeze dried) that I can find anywhere on the internet (that company went out of business) including the freeze dried offering on her site. She will send live kefir grains in a jar (to what countries, I don’t know).
How to make reuteri kefir/yogurt.
11-23-21
Skip the inulin. Probiotics and friendly yeasts utilize lactose generally. His whey is collected from Siggi’s. You can collect whey from any store bought kefir. The benefit addition is reuteri (a human milk strain) and fermentation time (increasing counts). Add colostrum and yogurt post ferment with milk and make a drink, (don’t know the yogurt temp. of insta pot setting but room temp. or gut temp. is ideal for colostrum).