Introduction To Colostrum
Colostrum is a biological fluid produced by the mammary gland after parturition, before it gradually loses its initial characteristics and to becomes mature milk. This secretion is fundamental for the survival of mammal offspring, especially for ungulates. Colostrum provides nutrition of newborns, enhances protection against pathogens, promotes the development of immune system and ensures the growth, maturation and repair of several tissues. Several studies have extensively analysed the composition of bovine, goat and human colostrum highlighting the presence of at least ninety different biologically active substances essential for specific functions.
The bioactive components of colostrum include:
1.) anti-microbial factors, 2.) immune stimulating peptides and 3.) growth factors.
Antimicrobial factors provide passive immunity and protect against infections, especially during the first weeks of life. The anti-microbial activity of colostrum can be direct on pathogen agents or indirect by stimulating the growth of a healthy intestinal microbiota rich in Bifidobacteria and Lactobacilli.
Colostrum provides signals to the immune system by inducing tolerance to food and noninvasive antigens, thus avoiding the onset of an abnormal immune response while promoting its maturation and an adequate immune response against pathogens at the same time.
Some components are able to promote the maturation and modulation of the immune system either directly as colostrinin, cytokines and lactoferrin, β-lactoglobuline, α-lactalbumin and glycomacropeptide or indirectly as oligosaccharides, gangliosides and nucleosides that favour the development of beneficial bacteria species. Furthermore, colostrum contains growth factors that play important roles in the development, maturation and repair of various tissues. In recent decades, BC have been used for the prevention and treatment of a variety of human and animal diseases, especially but not only of the gastrointestinal system.
Dr. Benjamin Frank, whose research on youth and aging, showed RNA to be one of our most critical anti-aging factors. His research showed that lgf-1 (found naturally in colostrum) is one of the only substances known to stimulate the growth and repair of these key nucleic acids, DNA and RNA.
Colostrum Benefits
Colostrum is bioactive with natural chymosin coating which protects against the stomach acid breaking down the natural components. Colostrum is a functional food that is
supercharged with over 97 immune factors and 87 known growth factors.
Colostrum offers the broadest possible spectrum of biologically active substances that promotes the development of a sound body.
It supports the activation and maintenance of a fully functional system; immune, nervous, skeletal, endocrine, pineal and more.
Unlike many natural supplements, Colostrum has great volumes of medical research to back up its claims. More than 25,000 scientific papers line the medical journals with documentation on colostrum’s ability to beneficially support a wide variety of health issues.
*All bovine colostrum is required by law to be a bio active substance before sale (must contain differing percentages IgG for humans or animals) and is always harvested within 24 hours if it is to be sold.
Introduction To Colostrum
What bovine colostrum and oral natural immune therapy has done for me for the umbrella syndrome known as SAM. See about page for more info.
*Bovine colostrum is a natural substance that can not be patented or synthetically re-produced all therapeutics featuring colostrum have either trademarked a name (Immuron® for example) or in the case of GcMaf, a proprietary method.
Part B of some of the conditions that I forgot. GC protein deficiency, by chemo type drug, it was a T cell destroying MS drug. The term CFS (chronic fatigue syndrome) and the first actual case that led to the terminology was due to a toxic event; (chemical spill) therefore CFS refers to this toxicity syndrome event involving tolulene, unless you’ve been exposed to tolulene you do not have CFS. Many toxic events have occurred in history with similar chemicals, benzene, kerosene etc. Toxicity and fatigue can worsen over time (and be severe) with many conditions but CFS is condition specific to a particular toxic event, I was not exposed. The major presidential initiative, ‘The War On Cancer’ ending in the 1970’s, failed to find cancer causing ‘viruses’, funding dried up and thus began the new fear mongering marketing technique where ‘epidemics’ du jour began to make headlines in order to boost ‘sales’ and raise research dollars, especially for ‘vaccines’. A thought provoking reminder, ‘Polio’ and ‘smallpox’ ‘vaccines’ remain remarkably successful? while all others based on more advanced ‘technology’ require many, many, many ‘boosters’ which should lead anyone to seriously question entire events. Colostrum prevents and treats endotoxemia. The genetic expression regarding mold is HLA-DR, I provide evidence in my book that this ‘genetic’ expression can be switched at will (with fish oil) undermining another concept that ‘genetic’ is a fixed state, just one of many written in stone concepts that I have helped expose over the years as being questionable. One more major illness I forgot, toxic shock syndrome.
If you prefer:
The bio-medical pioneers in GcMaf treatments (made with colostrum or whey) and products, now available in the US (Hawaii), Sasei Mirai. Bravo Yogurt® is also one of the first natural oral immune therapeutics made with colostrum, also now available in the US (2017). Immuron® is the first publicly offered stock pharmaceutical company based in Australia featuring colostrum based pharmaceuticals for treating numerous conditions such as IBD and liver disease.
Sasei Mirai Clinic, Japan. Now triple strength formula GcMaf. Post clinical trial info for the toxicity syndrome known as CV19.
Sasei Mirai
Bravo™ yogurt.
Bravo®
Alternavita: All you need to know (critical info in a nutshell)..... by focusing exclusively on these foundational health and immune development issues up to 90% of chronic conditions can be eliminated.
WHO STATEMENTS: 2017 Millennium Goal
- Breastfeeding,
- food (security)
- and water security (sanitation)
are major protective factors against malnutrition and critical factors in the maturation of healthy gut microbiota, characterized by a transient bifidobacterial bloom before a global rise in anaerobes. Early depletion in gut Bifidobacterium longum, a typical maternal probiotic, known to inhibit pathogens, represents the first step in gut microbiota alteration associated with severe acute malnutrition (SAM). Later, the absence of the Healthy Mature Anaerobic Gut Microbiota (HMAGM) leads to deficient energy harvest, vitamin biosynthesis and immune protection, and is associated with diarrhea, malabsorption and systemic invasion by microbial pathogens. A therapeutic diet and infection treatment may be unable to restore bifidobacteria and HMAGM.
Researchers found that malnourished children’s microbiota failed to follow the healthy pattern they identified in healthy children. The microbiota of malnourished children is immature, lagging in development behind that of their healthy peers. Supplementing these children’s meals with widely used therapeutic foods that increase calories and nutrient density reduces deaths from malnutrition, but it does not fix their persistent microbiota immaturity.
“Perhaps more insidious than slowing growth is malnutrition’s effect on less visible aspects of health, including impaired brain development and dysfunctional immunity, which follow these children throughout their lives”.
The Father of The Microbiome
Dr. Jeffrey Gordon
SIBO
SIBO can cause severe malabsorption, serious malnutrition and immune deficiency syndromes in children (non breastfed) and adults.
Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO.
Immunizations
The WHO recommends that immunization or treatment be orally administered due to economic, logistical and security reasons. Furthermore, this route offers important advantages over systemic administration, such as reducing side effects, as the molecules are administered locally and have the ability to stimulate the GALT immune responses (Levine and Dougan, 1998; Neutra and Kozlowski, 2006; Bermúdez-Humarán et al., 2011).
Infections
For ANY infectious or parasitic disease to start, it is ALWAYS a requisite that the host suffer IMMUNODEFICIENCY. At the same time, infectious and parasitic diseases themselves cause additional IMMUNE SUPPRESSION and more MALNUTRITION. This immune suppression is SECONDARY to the accumulation of free radicals, especially oxidizing species, that occurs during and after infectious and parasitic diseases.
Clinical Aspects of Immunology and Biochem J.
Current IBD Research 2016
Currently available treatments for IBD, which target the systemic immune system, induce immunosuppression, thereby exposing the patient to the risk of infections and malignancy. The interplay between the gut and the systemic immune system determines the final effect on target organs, including the bowel mucosa. Inflammatory bowel diseases (IBD) are associated with an altered systemic immune response leading to inflammation-mediated damage to the gut and other organs.
Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel
Most importantly, the immune modulatory agents used today for IBD do not achieve remission in many patients.
Not all IBD patients benefit from currently available drugs. Young people with IBD do not want to be on long-term drug therapy. Oral immune therapy, while not yet studied in large cohorts of patients, may provide an answer to this unmet need.
Clinical & Translational Immunology (2016)
Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel
Tolerance
Tolerance is the ability of the immune system to ‘see’ and respond appropriately. Without galactose (a necessary sugar) the immune system can not 'see'. Your immune system would not be able to function without galactose Your body wouldn’t know which cells are
“good” and what cells are “bad.” Your body wouldn’t know who the invaders were and which ones should be attacked by antibodies. As you will learn the importance of these ‘sugars’ in gut microbiota health is a rapidly expanding field of research, only recently
discovered, including HMO's (human milk oligosaccharides).
Why galactose?
Milk sugar aka lactose has been shown to be very beneficial for the human body though unlike sucrose, lactose is made up of glucose and galactose. There is no fructose in lactose. It is a healthy disaccharide sugar. Galactose is known as the “brain sugar” and supports brain development of babies and children. Galactose helps triggers long-term memory formation. Galactose has been shown to inhibit tumor growth and stop its spread, particularly to the liver. This beneficial sugar can also enhance wound healing, decrease inflammation, enhances cellular communication, and increases calcium absorption.
What does immune ‘tolerance’ mean in simple language?
Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to
substances or tissue that have the capacity to elicit an immune response in a given organism. The Th1 cytokine profile is vital for clearance of certain organisms and ancillary immune activity, and a limiting effect on this cytokine profile may result in reduced chances for overcoming infections especially intra-cellular organisms residing within macrophages.
Effective clearance will depend on appropriate macrophage activation (which occurs through IFN≥ release by Th1 and NK cells) and production of nitric oxide. If this pathway is disrupted IFN≥ secretion is blocked, impairing macrophage activation.
Persistent blockade of these inhibitory receptors has lead to the breakdown in immune self tolerance, thereby increasing susceptibility to autoimmune or auto-inflammatory side effects, including rash, colitis, hepatitis and endocrinopathies.
Many drugs may cause checkpoint blockade toxicity including pharmaceutical drugs termed ‘immuno therapy’ by pharmaceutical companies, these include Mab drugs and cancer treatments.
Checkpoint Inhibitor–Induced Colitis: A New Type of Inflammatory Bowel Disease?
Madeline Bertha, MD MS, corresponding author1 Emanuelle Bellaguara, MD, Timothy Kuzel, MD, and Stephen Hanauer, MD
ACG Case Rep J. 2017; 4: e112.
Published online 2017 Oct 11. doi: 10.14309/crj.2017.112
PMCID: PMC5636906
PMID: 29043290
The Elderly
Mammal milk is required for enhanced phagocytosis as shown by research, especially in the elderly. Whole fat mammal milk can actually restore phagocytosis in senescent cells in the elderly. Phagocytosis, by which immune cells ‘eat’ bacteria or infected cells, is one of the mechanisms that help to resist infections. Lactic acid bacteria strains like acidophilus also increases phagocytosis.